Given that, as mentioned, PKC represents a potential target of OCR and HIF-1α is one of the proteins activated by it, which in turn induces the production of VEGF, we first investigated the possible action of OCR on this inflammatory cascade, studying the protein content of PKCβII, HIF-1α, and VEGF in PBMCs from MS patients and HC. Here, SPIN1 is linked to myeloid sarcoma.