In the GSE152418 dataset, the expression level of UCHL1 in peripheral blood mononuclear cells (PBMCs) was significantly upregulated in COVID-19 patients (log2(FC) = 4.79, p-value = 7.2 × 10−6), consisting of 12 severe cases, 4 mild cases, and 1 convalescent case. This evidence concerns the gene UCHL1 and COVID-19.