CYCS and neuroblastoma: In this regard, Navarra et al. (2015) also observed that the interaction induced by adding citral (from bergamot EO) to doxorubicin therapy caused an increase in ROS levels, leading to alterations in mitochondrial membrane potential and the release of cytochrome c, as well as the activation of tumor suppressor genes and PCD pathways in SH-SY5Y human neuroblastoma cells [31].