ADORA2A and hereditary elliptocytosis: In addition, chronic intake of coffee alters the response of platelets to the activity of adenosine- or NECA-induced (NECA—non-selective agonist of adenosine receptor) platelet inhibition, and intake of caffeine for two weeks may upregulate A2A adenosine receptor activity, increase cAMP accumulation and anti-aggregatory effects, and decrease calcium levels elicited by HE-NECA.