Remaining in the cardiovascular context, metformin reactivates autophagic flux in cardiomyocytes after the treatment with crizotinib (a tyrosine kinase inhibitor used in anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancers), which induces high cardiotoxicity also through the block of autophagosome–lysosome fusion [24]. This evidence concerns the gene ALK and non-small cell lung carcinoma.