This initial assumption of apoptosis in pemphigus was mainly based on TUNEL assay results and other individual techniques used to disclose apoptosis, suggesting that the extrinsic pathway or cell death receptors of the tumor necrosis factor (TNF) family are involved in pemphigus pathology, including Fas (CD95) and its cognate ligands, which can be found in blisters or their vicinity. This evidence concerns the gene FAS and pemphigus.