For instance, PRMT1, which is responsible for over 90% of arginine methylation, has been shown to promote migratory and invasive behaviors in BC cells by mediating the asymmetric dimethylation of R3 residue of histone H4 (H4R3me2as) at the ZEB1 promoter, thus inducing processes linked to epithelial–mesenchymal transition (EMT) [23]. This evidence concerns the gene ZEB1 and breast cancer.