Specifically, while ADCYAP1R1 expression was still not significantly affected in the NAWM of RRMS cases vs. non-MS cases (t9 = 0.125; p = 0.9036; Figure 3A′), transcript levels were significantly downregulated in PPMS (t8 = 2.681; * p < 0.05; Figure 3A′′). The gene discussed is ADCYAP1R1; the disease is myeloid sarcoma.