The cancer cells of the CMS4 subtype reprogram lipid metabolism due to the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway, via triacylglycerol lipase (TAG) carboxylesterase 1 (CES1), thus establishing a connection between obesity-associated inflammation and metabolic adaptation [36]. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.