In addition to anthropometric measurements indicative of overweight and obesity, selected parameters reflecting metabolic syndrome (hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterinemia, high LDL and low high-density lipoprotein (HDL), and hypertension) and inflammation (high C-reactive protein and IGF-1) can elevate the risk of CRC [237,238,239,240]. Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.