Up to 65–70% of sporadic CRCs present CIN, whose main features are the activation of WNT signaling, mutational inactivation of APC, and mutational inactivation/deletion of tumor protein 53 (TP53) [112], although mono-ADP ribosylhydrolase 2 (MACROD2) microdeletions can also be observed in a smaller fraction of this type of colorectal tumors [113]. Here, MACROD2 is linked to cervical squamous intraepithelial neoplasia.