Here we studied mRNA levels for GHRH and SVs of GHRH-Rs using RT-PCR, the manifestation of the GHRH-R protein by Western blot and binding characteristics of GHRH-R SV1 using a radiolabeled receptor assay in a cohort of human pediatric neoplastic conditions including Hodgkin lymphoma (HL), rhabdomyosarcoma (RMS), teratoma (TR), acute lymphoblastic leukemia (ALL), fibrous dysplasia (FD), benign mesenchymal hamartoma (BMH), juvenile myofibromatosis (JM), chronic benign neutropenia (CBN), hereditary spherocytosis (HS) and immune thrombocytopenia (ITP) [15]. This evidence concerns the gene GHRHR and hereditary spherocytosis.