COL3A1 and Ehlers-Danlos syndrome, vascular type: Studies suggest that collagen III might provide ‘flexibility’ in these soft tissues [16], and hence the rupture of internal organs, particularly vascular rupture, is commonly reported in Ehlers–Danlos Syndrome type IV; vascular type (vEDS, EDS type IV; MIM #130050) caused by COL3A1 mutations.