In the comparison of the transcriptome profile of vehicle treated animals on Day 1, 24 h after 9.2 Gy TBI to the profile of nonirradiated, vehicle-treated animals on Day 0 (24 h after the last dose) or Day 1 (48 h after the last dose) showed significant activation of radiation-response-related signaling pathways in animals exposed to radiation, such as acute phase response signaling, pulmonary fibrosis idiopathic signaling, thrombin signaling, complement system, and interleukin 8 (IL-8) signaling, which were all present in the top 25 enriched pathways (Figure 3A). This evidence concerns the gene CXCL8 and pulmonary fibrosis.