APOE and Alzheimer disease: Moreover, we identify genome-wide significant genes (Fisher’s combined p value [FCPgene] < 2.60 × 10−6) shared across AD, several lipids, and CAD traits, including WDR12, BAG6, HLA-DRA, PHB, ZNF652, APOE, APOC4, PVRL2, and TOMM40.