Consistent with previous studies [14,35,64], our study revealed that APOE, TOMM40, and many genes on chromosome 19 are shared across AD, multiple lipids (such as HDL, LDL, triglycerides, and total cholesterol), and CAD traits (including coronary arteriosclerosis, myocardial infarction, and ischemic heart disease). Here, APOE is linked to Alzheimer disease.