Assessing overlap between GWS (Pgene < 2.60 × 10−6) genes for AD, lipids, and CAD traits, that is, sentinel genes; we found two (APOE and ZNF652) that were shared by AD and angina pectoris (Supplementary Table S17), five (APOC1, APOE, PVRL2, TOMM40, and ZNF652) by AD and both coronary arteriosclerosis (Supplementary Table S17) and ischemic heart disease (Supplementary Table S17), three (APOC1, APOE, and TOMM40) by AD and myocardial infarction (Supplementary Table S17), and five (APOC4, APOC4-APOC2, APOE, CTB-129P6.11, and TOMM40) by AD and HDL (Supplementary Table S17). Here, APOC4 is linked to Alzheimer disease.