Starting from previous observations showing that the long-term loss of keratinocyte desmoglein 1 (Dsg1) promotes pagetoid movement of melanocytes, an upward intraepidermal spread that mimics a malignant phenotype in 3D organotypic cultures [29], the authors [160] examined Dsg1 expression in the epidermal niche of melanoma cells. Here, DSG1 is linked to melanoma.