INS and ischemia: Considering that Captopril and LQM312 can replicate the interaction between AMP and the AMPK subunit, as proposed in these in silico studies, they may also enhance AMPK phosphorylation and may activate the GLUT4 trafficking signaling pathway since it has been reported that AMPK activation is responsible for glucose uptake in hearts subjected to ischemia by increasing the intracellular translocation of GLUTs to the membrane through a signaling pathway distinctly different from insulin.