On the other hand, it was demonstrated that neuroserpin may also have a beneficial and neuroprotective function during stroke because of its role in regulating excessive and uncontrolled tPA activity [21,22,23], Once again, we have shown that lox-1 mediated Mox-LDL signaling modulates neuroserpin activity in endothelial cells, which could have major implications that are not exclusive to the pathophysiology of ischemic strokes but are also connected to additional pathologies including Alzheimer’s disease and other mental illnesses [17]. The gene discussed is PLAT; the disease is early-onset autosomal dominant Alzheimer disease.