An example was reported by Stefano et al. (2022) of a new Pt (II)-complex containing 1,10-phenanthroline (phen), [Pt(η1-C2H4OMe)(DMSO)(phen)]Cl, with a decrease in cell migration/invasion in 2D and 3D in vitro models and decreasing MMP-9 and MMP-2 expression and activity in Neuroblastoma cells [43]. Here, MMP9 is linked to neuroblastoma.