Validated targets of miR-129-5p are CAMTA1 (calmodulin-binding transcription factor), indicating a role of calcium under this condition, SOX4 (regulation of Wnt pathway), GALNT1 (modifying glycan structures), EIF2C3 and HMGB1, which has been shown to protect against ischemia/reperfusion injury [32]. Here, HMGB1 is linked to ischemia.