Muiño reviewed 34 cases with a clinical suspicion of CADASIL and cysteine-sparing NOTCH3 missense mutations and concluded the following criteria for pathogenic identification: (1) the patients had typical clinical CADASIL syndrome; (2) the patients had diffuse WMHs in MRI; (3) the study analyzed the 33 exons of the NOTCH3 gene to rule out other pathogenic mutations; (4) the mutation had a MAF < 0.1%; and lastly (5) the patients had GOM deposits in the skin biopsy [4]. This evidence concerns the gene NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1.