NOTCH3 and CADASIL: In nine studies (519 typical CADASIL patients) with specific mention of these two radiological features, the prevalence of WMHs in the anterior temporal lobe was 57.42% and that in the external capsule was 77.84%, which are significantly higher than those of patients with NOTCH3 cysteine-sparing mutations (10.50% and 25.11%, respectively).