INS and diabetes mellitus: The diagnostic criteria of the Practice Guideline for MODY in 2008 comprise early onset of diabetes before 25 years of age, history of diabetes in two consecutive generations, absence of pancreatic β-cell autoimmunity, and preserved β-cell function defined by the lack of insulin treatment or serum C-peptide levels > 200 pmol/L after 3 years of insulin therapy [3].