The characteristics are readily observed in RBPs that are commonly seen to be incorporated in pathological biomolecular condensates found in a broad range of neurodegenerative disorders, such as the RBPs TDP-43, FUS/TLS, EWS, and RBM45 that are key to the pathological NCIs of ALS [58,59]. Here, EWSR1 is linked to amyotrophic lateral sclerosis.