The presence of diffuse microglial activation in the brainstem, including microglial nodules, astrogliosis, and perivascular inflammation with parenchymal CD3+ and CD8+ T cells, further supports the concept that the acute neurological manifestations of COVID-19 are the consequence of a prominent neuroinflammatory process in the absence of robust evidence of ongoing SARS-CoV-2 infection of the brain [72,77,78,79]. The gene discussed is CD8A; the disease is COVID-19.