The exhausted population in the tumor dramatically overexpressed ICOS (15.4-fold change) compared to peripheral NK cells (PBMCs: 0.7673; TILs: 11.79; p < 0.0001), while 4-1BB was overexpressed 10.6-fold in TILs compared to PBMCs (PBMCs: 0.7073; TILs: 7.474; p = 0.0001) (Figure 5). The gene discussed is ICOS; the disease is neoplasm.