In addition, WDR5 ablation effectively results in the downregulation of immune checkpoints (PD-1, PD-L1, and Spp1) and immunosuppressive cytokines (TGFβ and IL6) in pancreatic tumor microenvironments, leading to improved CD8+/CD4+ T-cell infiltration. The gene discussed is TGFB1; the disease is pancreatic neoplasm.