H3K4me3 not only modulates anti-cancer immunity, such as enhancing cancer-antigen [22,23] and MHC molecules’ expression [24,25], promoting T-cell development [26,27,28,29] and chemokine-induced T-cell trafficking [30], improving DCs’ maturation [31], but also regulates pro-cancer immunity, such as promoting immune-checkpoint expression [18,19,32,33], supporting M2 polarization of TAMs [34,35], and facilitating immunosuppressive functions of MDSCs [36,37,38]. Here, HLA-C is linked to cancer.