On the other hand, Wdr5 depletion leads to the downregulation of immune checkpoints, including PD-1, PD-L1, and Spp1; and immunosuppressive cytokines, including TGFβ and IL6, in the tumor microenvironments to overcome the pro-cancer effect caused by Wdr5 deficiency-induced MHC I transcription inhibition. The gene discussed is SPP1; the disease is neoplasm.