Although the function of the WDR5/MLL1-H3K4me3 axis has been extended from leukemia to solid tumors such as pancreatic cancer [18,19], the relative functions of the WDR5/MLL1-H3K4me3 axis in tumor cells and immune cells in solid tumor is incompletely studied. This evidence concerns the gene WDR5 and familial pancreatic carcinoma.