In MASH samples, we found an enhanced expression of ACE, MMP2, MMP7, and MMP9, of which ACE, MMP2, and MMP7 were inversely correlated with the corresponding Aβ-42 tissue levels, indicating a regulatory role for Aβ-42 in MASLD. The gene discussed is MMP2; the disease is metabolic dysfunction-associated steatotic liver disease.