Of note, UCHL1 (Ubiquitin C-terminal hydrolase 1), an important player in the elimination of oxidized or misfolded proteins and known to decrease BACE1-catalyzed cleavage [40], is increasingly expressed in the tissue samples of patients with MASH and severe fibrosis, and inversely correlates with Aβ-42 levels. This evidence concerns the gene BACE1 and metabolic dysfunction-associated steatohepatitis.