Additionally, we found unchanged BACE1 mRNA in vitro, but a reduced BACE1 protein expression in the livers of HFD mice, which might be due to increased Nrf2 (nuclear factor erythroid-derived 2-related factor 2, NFE2L2) activity under oxidative stress in hepatic steatosis [24]. This evidence concerns the gene BACE1 and Hepatic steatosis.