Xanthoxylin treatment (1, 2.5, 5, 10 mg/kg) significantly inhibited oxidative stress in LPS-induced ALI (p < 0.005 for MDA and p < 0.05 for SOD), suggesting Xanthoxylin’s role in reducing oxidative stress at 1–10 mg/kg. The gene discussed is SOD1; the disease is acute respiratory distress syndrome.