Our group has previously reported that in HNSCC, the ∆Np63-dependent regulation of hyaluronic acid (HA) impacts chemosensitivity, likely through the ABC transporter ABCC1 [31], suggesting the existence of a functional link between ∆Np63 transcriptional activity and ABCC1 expression. This evidence concerns the gene ABCG2 and head and neck squamous cell carcinoma.