IL33 and Hyperkeratosis: Our histological and immunohistochemical studies demonstrated that the skin of the TG mice has a thickened epidermis with mild hyperkeratosis, a marked accumulation of M1 and M2 macrophages around adipose tissue in the lower dermis and a marked increased expression of IL-33 in the nuclei of the keratinocytes in the spinous layer compared to the WT mice.