As for the increased expression of IL-33 in the depilatory cream-treated dorsal skin of TG mice without any visible skin inflammation, available evidence indicates that intracellular IL-33, which is mainly distributed in the nuclei of basal and suprabasal epidermal keratinocytes, is distinctly expressed at higher levels throughout the epidermis of AD lesions compared with HC skin [32,33,34]. Here, IL33 is linked to dermatitis.