FN1 and obesity due to melanocortin 4 receptor deficiency: Our data indicate that circulating levels of FN1 are upregulated in the NR-PE group (Figure 1), which agrees substantially with findings from prior studies that have demonstrated increased levels of this protein in preterm delivery (which exhibits symptoms and risk factors that are similar to PE) compared to term delivery [11,12] in women who develop the disorder versus healthy pregnancy [13,14], as well as in gestational diabetes and obesity [12].