MYCN and neuroblastoma: These biomarkers are related to the underlying mechanisms influencing NB progression, as an impairment of cell cycle regulation mediated by MYCN and ALK targets [42,43]; telomere maintenance mechanisms, especially alternative telomere elongation, which maintains undefined cell survival and division [41,44]; and neuroblast plasticity cause a partial transition from noradrenergic to migratory and chemoresistant mesenchyme cells [45,46].