STAR and breast cancer: Specifically, while StAR K111Q and K253Q acetylation mutants were found to increase the biological activity of StAR for the subsequent synthesis of E2, deacetylation mimetic events involving these lysine residues affected StAR and suppressed E2 buildup in BC cells, elucidating the relevance of StAR acetylation-based mechanistic events in E2 regulation in mammary tissue.