HSD3B2 and schizophrenia: Although molar ratios that may reflect HSD3B functioning do not show a significant consistent trend in our present results in relation to schizophrenia, molar ratios in the key pathway leading to cortisol synthesis are significantly lower (17-OH-P/17-OH-PREG and 17-OH-P/17-OH-PREGS) in patients compared to controls.