Furthermore, in a study related to CKD, apixaban significantly reduced markers like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and von Willebrand Factor (VWF) while normalizing reactive oxygen species (ROS) levels in endothelial cells exposed to uremic serum [186]. This evidence concerns the gene VWF and chronic kidney disease.