Male diabetic mice models, specifically eNOS+/+DM, eNOS+/-DM, and eNOS−/−DM, to investigate the effects of FXa inhibition. Effects of PAR2 absence on DN were assessed using F2rl1−/−; Ins2Akita/+; eNOS+/- mice and compared to F2rl1+/+; Ins2Akita/+; eNOS+/- mice. The gene discussed is F10; the disease is liver dysplastic nodule.