The association of acriflavin, an inhibitor of HIF-1α/HIF-1β dimerization, with PDT with PS 5-aminolevulinic acid (5-ALA-PDT) reduced the expression of HIF-1α, GLUT-1, GLUT-3, and HK2, improved the efficacy of the treatment of refractory GBM, and reduced tumor cell invasion and migration [55]. This evidence concerns the gene SLC2A3 and neoplasm.