The association of acriflavin, an inhibitor of HIF-1α/HIF-1β dimerization, with PDT with PS 5-aminolevulinic acid (5-ALA-PDT) reduced the expression of HIF-1α, GLUT-1, GLUT-3, and HK2, improved the efficacy of the treatment of refractory GBM, and reduced tumor cell invasion and migration [55]. The gene discussed is HIF1A; the disease is neoplasm.