ESR2 and neoplasm: Furthermore, eight target genes (COL4A3, FAM30A, FCRL5, MDM4, SYNE2, TNFRSF13C, TPTEP2, VAMP1) were systematically positively correlated with ESR2 expression patterns in tumor types with low ESR2 expression as a prognostic factor concerning OS or DFS (Figure 5c).