Notably, our findings highlight seven genes (FAM30A, MDM4, POU2AF1, SYNE2, TNFRSF13C, TPTEP2, VAMP1) presenting positive correlations with ESR2 expression patterns in all tumor types with high ESR2 expression as a positive prognostic factor with regard to OS or DFS (Figure 5a). Here, MDM4 is linked to neoplasm.