ESR2 and glioblastoma: In KICH (p-value < 0.000001) (Figure S3), KIRC (p-value = 0.00002) (Figure 3d), and glioblastoma multiforme (GBM) (p-value = 0.003) (Figure S3), a low ESR2 expression level was associated with longer DFS, regardless of sex.