ESR2 and lung adenocarcinoma: A negative correlation was found for lung adenocarcinoma (LUAD) (p-value = 0.000367), testicular germ cell tumor (TGCT) (p-value = 0.0172), and thyroid carcinoma (THCA) (p-value = 0.0143), showing lower ESR2 expression levels correlated with tumor stage (Figure 2a).