After 90 days of treatment, the DW control group had lower HGB (p < 0.0001 vs. SPF; p = 0.0002 vs. HE; p < 0.0001 vs. fdHE; p = 0.0046 vs. Yext) and HCT (p = 0.0044 vs. SPF; p = 0.0006 vs. HE; p < 0.0001 vs. fdHE; p = 0.0002 vs. Yext) values compared with the SPF control and all treated groups. Here, CYGB is linked to hereditary elliptocytosis.