CDKN2A and central nervous system cancer: Among these age-related diseases, genome-wide association studies (GWASs) and candidate analyses have demonstrated that non-coding regulatory polymorphisms in the vicinity of the CDKN2A locus, which encodes p16INK4A, ARF, and p15INK4B, are responsible for the lifetime risk of melanoma, pancreatic cancer, leukemia, and glioma [21].