Livers of mice with leptin deficiency presented lower protein expression of the subunits of complexes II and V (SDHB and ATP5A), whereas no effect on the subunits of the other ETC complexes was observed (Figure 4), suggesting that remodeling of the hepatic ETC was associated with leptin deficiency. Here, LEP is linked to hyperinsulinemic hypoglycemia, familial, 4.