This observation, coupled with the presence of pathogenic variants in ALS patients at this precise location, Lys510Gln (K510E), Lys510Arg (k510R), and Lys510Met (K510M), supports the idea that lysine 510 acetylation must play an important role in FUS function and its role in ALS [102,103,104]. Here, FUS is linked to amyotrophic lateral sclerosis.