PRKN and hepatocellular carcinoma: Consistently, a number of studies on various PINK1/Parkin-null mouse models have demonstrated that PINK1/Parkin is closely involved in the susceptibility to spontaneous hepatocellular carcinoma (HCC) [134], the sensitivity to irradiation-induced lymphomagenesis [135], and the increase in tumor burden and metastasis in oncogenic K-Ras-driven pancreatic cancer [136,137].