In CML, autophagy genes such as ATG4, ATG5, and BECN1 are reported to be upregulated and impairing this autophagy, either by silencing ATG7 or ATG4 or by treating with HCQ, sensitizes CML to chemotherapeutic treatments [79,80] (Figure 3). The gene discussed is BECN1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.