Upon the knockout of RB1CC1 (encoding FIP200/ATG17, a one of key component of ULK1 complex), the inactivation of the EGFR-STAT3 signaling axis was observed, and consequently, there was an impairment of ALDH+ breast cancer stem cells’ (BCSCs) tumorigenicity. The gene discussed is STAT3; the disease is breast carcinoma.