In CML, autophagy genes such as ATG4, ATG5, and BECN1 are reported to be upregulated and impairing this autophagy, either by silencing ATG7 or ATG4 or by treating with HCQ, sensitizes CML to chemotherapeutic treatments [79,80] (Figure 3). Here, ATG5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.