A study by Loft et al. reported that knockdown of ELF3 and GLIS2 in a mouse model of liver fibrosis leads to altered expression of the hepatocyte biomarker Abcc4 and fibrosis-related signature genes, including Spp1 and Ctgf, contributing to HSC activation and liver fibrosis development [188]. The gene discussed is ABCC4; the disease is Hepatic fibrosis.