EDNRB and hypertensive disorder: Conversely, female ETB receptor-deficient rats develop more severe hypertension on a high-salt diet than males, and gonadectomy increases the responsiveness of the afferent arteriole to ETB-induced vasoconstriction in females, but not males, indicating that female sex hormones may inhibit ETB-mediated vasoconstriction in the renal microcirculation [104,106].