In a cohort of PCD subjects that are affected by chronic respiratory disease, we aimed to investigate (1) whether they are more susceptible to SARS-CoV-2 infection and (2) whether the polymorphisms of the TAS2R38 bitter taste receptor correlate with a greater prevalence of SARS-CoV-2 infection and symptom severity. This evidence concerns the gene TAS2R38 and primary ciliary dyskinesia.