RB1 and neoplasm: Although AR can promote PCa growth, it has also been demonstrated to be a potent tumor suppressor that inhibits proliferation by acting on genes that influence DNA replication, synthesis, modification, and repair (e.g., MCM7 [minichromosome maintenance complex gene], FANCI [Fanconi anemia complementation group gene]) by way of retinoblastoma protein (RB) recruitment, particularly when DHT is present [18].