For example, it is well known that the restoration of AR signaling in the human PCa-derived AR-null cell line PC3 attenuates cell growth rate, while the androgen-sensitive human PCa line LNCaP, that expresses a mutant AR, is growth-stimulated at low androgen levels but repressed at high levels of androgens [15,18]. The gene discussed is AR; the disease is posterior cortical atrophy.