Dogs, unlike humans, do not express prostate specific antigen (PSA), but FOLH1 (folate hydrolase 1), the gene encoding the enzyme prostate specific membrane antigen (PSMA), an AR target that is upregulated in human PCa, was also upregulated with AR restoration in 1508 (5-fold) and Leo (3.5-fold) but not with 1258. The gene discussed is KLK3; the disease is posterior cortical atrophy.