Mutations in genes associated with mitochondrial fusion, including OPA1, AFG3L2, and MIEF1, lead to autosomal dominant optic atrophies (DOAs), specifically optic atrophy 1 (OPA1), optic atrophy 12 (OPA12), and optic atrophy 14 (OPA14), respectively. Here, OPA1 is linked to autosomal dominant optic atrophy.