MECR and optic atrophy 15: Mutations in lipid metabolism-related genes, including malonyl CoA:ACP acyltransferase (MCAT) and mitochondrial trans-2-enoyl-CoA reductase (MECR), are responsible for autosomal recessive optic atrophy 16 (OPA15) and optic atrophy 15 (OPA16), respectively [88,89,90].