Enhancer regions and motifs specific to key transcription factors, including JUN, MYC, SMAD3, E2F1, SP1, CTCF, SMAD4, STAT3, NFKB1, and KLF4, were enriched in differential loci ATAC-seq peaks of dormant and reactivated cancer cells induced by chemotherapy. Here, SMAD3 is linked to cancer.