However, due to the pluripotent effect of canonical NFκB signaling, there was a synergistic cancer-promoting effect of the combination of NFκB and EZH2, which was detected both at the level of cell culture and cancer subcutaneous xenografts in mice, as well as at the level of glioblastoma patient prognosis, evident both in disease-free survival and in overall survival [102]. Here, EZH2 is linked to glioblastoma.