However, 2-hydroxyglutarate accumulation can also cause aberrations in the regulation of chromatin remodeling and oxidant stress, which could also predispose mutated isocitrate dehydrogenase AML cells to a divergent response to inflammation, with a selective NFκB-driven impact on stromal cells [188,189]. This evidence concerns the gene NFKB1 and acute myeloid leukemia.