However, in patients with Luminal A breast invasive carcinoma, there was a negative correlation found between ESR1 and CXCL3, CXCL5, and CXCL6 gene expression; and in Her-2 patients, the same relationship was seen between ESR1 and CXCL6. This evidence concerns the gene CXCL6 and invasive breast carcinoma.