Figure 7J shows the gating image for IELs. Administration of a probiotic mixture affected the frequencies of neutrophils in 8-week-old colitis mice. Probiotic mixture administration significantly downregulated the cell frequencies of Ly6G+ in PBL (p < 0.05) and CD11b+ cells in the spleen (p < 0.05) compared to colitis mice. Additionally, the frequencies of CD11b+Ly6G+ cells were significantly reduced in the PBL and spleen of colitis mice after receiving the probiotic mixture (p < 0.05) (Figure S2). Here, ITGAM is linked to colitis.