This study aimed to investigate the anti-obesity and anti-diabetic effects of LCM hot water extract by examining GLP-1 secretion in NCI-h716 cells, assessing lipid accumulation and expression of lipogenic and adipogenic factors in 3T3-L1 adipocytes, and analyzing the weight and biochemical changes induced by LCM treatment in a high-fat diet-induced model. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.