RASopathy patients exhibit alterations in the expression and activation of proteins in several signaling pathways, including RAS/MAPK, PI3K/AKT/mTOR, Rho/ROCK/LIMK2/cofilin, cAMP/PKA, JAK/STAT, Hippo, Wnt/β-catenin, and TGF-β [14,15,16,17]. This evidence concerns the gene CFL1 and RASopathy.