These studies, along with the interplay between the Hippo pathway and the RAS/MAPK and PI3K/AKT/mTOR pathways mediated by core Hippo kinase proteins (MST1/2 and LATS1/2) [14], suggest that investigating Hippo pathway components as biomarkers could yield novel diagnostic and monitoring tools for RASopathies, improving disease management and treatment outcomes. Here, AKT1 is linked to RASopathy.