KRAS and colorectal carcinoma: The presence of mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS), and aberrant hypermethylation of promoter regions N-Myc Downstream Regulated Gene 4 (NDRG4) and Bone Morphogenic Protein 3 (BMP3) [42,43], are closely associated with the presence of CRC and advanced adenomas.